Synapse-Specific Metaplasticity: To Be Silenced Is Not to Silence 2B
نویسندگان
چکیده
What happens to a single, presynaptically quiescent synapse among a population of active synapses? In this issue of Neuron, Ehlers and colleagues show that, far from being eliminated, these inactive synapses are primed for potentiation and incorporation into a new neural circuit through an upregulation of NR2B-containing NMDA receptors.
منابع مشابه
Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II.
Virtually all CNS synapses display the potential for activity-dependent long-term potentiation (LTP) and/or long-term depression (LTD). Intriguingly, the potential to exhibit LTP or LTD at many central synapses itself is powerfully modulated by previous synaptic activity. This higher-order form of plasticity has been termed metaplasticity. Here, we show that inhibitory autophosphorylation of Ca...
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Ca2+ influx, causing insertion of new GluR1-containing AMPARs into the postsynapse after which unidentified subsequent events adapt the presynaptic elements. However, such a model is in contrast to recent findings in other systems in which preor postsynaptic modifications had been described (for review see Burrone and Murthy, 2003). The discrepancy may be due to differences in developmental sta...
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ورودعنوان ژورنال:
- Neuron
دوره 66 شماره
صفحات -
تاریخ انتشار 2010